General Information

  • ID:  hor002850
  • Uniprot ID:  Q95P23
  • Protein name:  ENq
  • Gene name:  ENPP
  • Organism:  Aplysia californica (California sea hare)
  • Family:  NA
  • Source:  animal
  • Expression:  High expression in gut and CNS.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QPSYTHAFV
  • Length:  9(677-685)
  • Propeptide:  MAKHDVTVMTLLLVVCALHVFDAQGTDVKLNDGFLRSGIMNIPFQRRVSPKYGHNFVGKRSGFQSPVSPSDYFIPDELNDEDESPNMDTYALFRELLGEYPSSELSDDDVIRPYPVVPWAWDRFENKRFSKENEKRGSPGFSHSFVGKRMDLSALEKELIAKLKAADLLSPLETEAPGKRRLPSYGHSFLGKRMPVDVFPRAIPSYSHNFVGKRSGNGENYFDDLDTFGDISQRADLGFTHSFVGKRGNTDFSRN
  • Signal peptide:  MAKHDVTVMTLLLVVCALHVFDAQG
  • Modification:  T1 Pyrrolidone carboxylic acid;T9 Valine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Enterins inhibited contractions of the gut. In the CNS, the cerebral and buccal ganglia, which control feeding, contained the enterins; Enterins reduced the firing of interneurons B4/5 during feeding motor programs which corresponded to a switch from eges
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q95P23-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002850_AF2.pdbhor002850_ESM.pdb

Physical Information

Mass: 119202 Formula: C49H68N12O14
Absent amino acids: CDEGIKLMNRW Common amino acids: AFHPQSTVY
pI: 7.54 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -25.56 Boman Index: -748
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 43.33
Instability Index: 4225.56 Extinction Coefficient cystines: 1490
Absorbance 280nm: 186.25

Literature

  • PubMed ID:  11588196
  • Title:  The Enterins: A Novel Family of Neuropeptides Isolated From the Enteric Nervous System and CNS of Aplysia